What is kidney fibrosis

Written By The HealthMeth Team - Updated On Saturday, March 13, 2021 6:00 PM

Kidney cirrhosis

Happens cirrhosis of the kidney in the beginning as a natural reaction to the body of the damage in the renal tissue, and the demise of the cause of the damage heals tissue and back to normal, but in the event of continuing cause of damage and kidney damage, accumulate scars and loses tissue properties In fact, pathological fibrosis occurs in the kidney tissues , and with the continuation of the fibrosis, the tissue loses its ability to heal, and the difficulty of blood supply to nourish the renal tissue increases, which ultimately leads to the occurrence of kidney failure, and it is worth noting that kidney cirrhosis may occur as a result of a person suffering from any of the chronic and progressive kidney diseases , especially in its advanced stages, as it is one of the main causes of the progression of chronic kidney disease to the stage The final stage , and fibrosis may affect many other organs in the body, such as the lungs and liver , and it should be noted that fibrotic diseases cause nearly half of the deaths in the developed countries of the world annually. [1] [2]

Kidney cirrhosis treatment

Scientists have not yet been able to find an effective treatment for cirrhosis or any of the other cirrhotic diseases that affect the various organs in the body, and because the fibrosis process is considered one of the vital repair processes that the body performs to try to reduce the damage to the tissues and repair it, it enters into this process There are many different factors and cells, and they are done in a very complex way, but there are some therapeutic methods that have been reached, or are currently being tested to reduce the progression of kidney cirrhosis, and these methods include the following: [3]

  • Medicines directed against the renin- angiotensin system are the first-choice drugs for treatment in cases of cirrhosis and angiotensin converting enzyme inhibitor, along with angiotensin II receptor blocker drugs. The kidneys, although these drugs are not able to completely prevent the progression of kidney cirrhosis, but they help to reduce the speed of the disease progression, and the use of kallikrein enzymes and antagonists of aldosterone receptor have shown the ability to reduce Kidney cirrhosis progresses.
  • Moxonidine: Moxonidine blocks the activity of the sympathetic nerve, slowing the progression of cirrhosis.
  • Statins: This drug works to reduce scarring of kidney tissue, and this may be attributed to its ability to reduce blood lipids , and through the drug's anti-inflammatory properties.
  • Avoid factors that contribute to the development of the disease: by avoiding smoking, as it has been found that smoking increases the speed of progression of kidney cirrhosis, and by losing weight and avoiding eating foods rich in fats that stimulate kidney cirrhosis.

Symptoms of chronic kidney disease

Kidney cirrhosis is the main cause that leads to the development of chronic kidney disease into the final stage of disease [3] . In fact, the progression of chronic kidney disease is accompanied by the appearance of some different symptoms and signs, including the following: [4]

  • Nausea .
  • Vomiting.
  • Loss of appetite .
  • Feeling tired and weak.
  • Sleep problems and disturbances.
  • Change in the number of times you urinate.
  • Muscle tightness and cramps .
  • Swollen feet and ankles.
  • Feeling of constant itching.
  • Feeling of chest pain, if fluid accumulates in the area around the heart.
  • Weak breathing, if fluid builds up in the lung.
  • High blood pressure , with difficulty controlling it.

Causes of chronic kidney disease

Chronic kidney disease occurs as a result of a disease or health condition that impairs kidney function , which leads to damage to it. Chronic kidney disease may develop over many months and years. Among the reasons that lead to the development of chronic kidney disease are the following: [4]

  • Having diabetes type 1 or type 2.
  • Hypertension.
  • Glomerulonephritis.
  • Interstitial nephritis.
  • Polycystic kidney disease.
  • Blockage of the urinary tract for a long time due to a number of health conditions such as an enlarged prostate, or due to the formation of kidney stones , or due to cancer .
  • Vesicoureteral reflux, which is a condition that causes urine to back up into the kidney.
  • Pyelonephritis.

Complications of chronic kidney disease

The progression of chronic kidney disease affects almost all parts of the body, and complications that accompany the progression of the disease include: [4]

  • Fluid retention in the body, causing swelling of the hands and feet, and the patient shows high blood pressure, and pulmonary edema may also form.
  • Hyperkalemia, in which a sudden increase in the level of potassium in the blood occurs, which threatens the patient’s life as a result of its effect on the work of the heart.
  • Heart and arterial disease .
  • Weakened bones and increased fracture risk.
  • Anemia.
  • Erectile dysfunction (erectile dysfunction) in men, decreased libido, and fertility problems.
  • Difficulty concentrating and nerve spasms, as a result of damage to the central nervous system.
  • Weak immune response, which leads to easy infection of diseases.
  • Pericarditis, which is an inflammation of the membrane surrounding the heart.


  1. Benjamin D. Humphreys (16-10-2018), “Mechanisms of Renal Fibrosis” , Annual Review of Physiology , Issue 80, Page 309-326. Edited.
  2. Peter Boor, Tammo Ostendorf, Jürgen Floege (9-14-2010), “Renal fibrosis: novel insights into mechanisms and therapeutic targets” , Nature Reviews Nephrology , Issue 6, Page 643--656. Edited.
  3. ^ A b Peter Boor, Katarína Šebeková, Tammo Ostendorf, "Treatment Targets In Renal ' brosis" , Nephrology dialysis Transplantation , Issue 22, 3391-3407 . Page.
  4. ^ A b T. "Chronic renal DISEASE" , Www.mayoclinic.org , 8-3-2018, Retrieved 5-4-2018. Edited